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Abstract
Recently, a role of β-Endorphin on peripheral tissue metabolism has been suggested. A lipolytic effect of β-Endorphin has been observed both in vivo and in vitro in animals but, at present, there is no evidence for a similar effect in humans. In this study, we investigated the lipolytic effect of β-Endorphin in isolated human adipocytes. B-Endorphin induced a significant increase in glycerol release in isolated human fat cells. Naloxone was able to inhibit the β-Endorphin-induced lipolysis. The opioid antagonist alone had no effect on basal lipolysis and on Epinephrine-stimulated lipolysis when administered together with this hormone. Our results suggest that β-Endorphin may play a role on lipolysis also in human fat cells and that this effect may be mediated by a specific opiate receptor.
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