Abstract
It has been demonstrated that the removal of lipoids from Type I antipneumococcus horse serum causes a loss of the visible phenomena of type specific agglutination and precipitation, and in the case of rabbit serum a marked reduction in these properties. Initial activity of the type specific antibody can be restored to extracted immune horse serum by the addition of lecithin, and to rabbit serum by the addition of cephalin. The significance of these observations in respect to the relation of phospholipins to the type specific reactions of antipneumococcus serum is discussed.
Highlights
It has been recognized that the antibacterial sera produced by the immunization of the horse and the rabbit with Type I pneumococci, possessing type specificity, exhibit marked differences in certain immunological properties
In confirmation of the prozone phenomenon with immune horse serum, the protocols of other workers demonstrate the failure of greater than optimal amounts of horse serum to protect (Yosioka (6), Felton (7) and Sobotka and Friedlgnder (8)). It has been repeatedly shown by Felton (9) that the immune globulin fraction of antipneumococcus horse serum is precipitated by tenfold dilution with distilled water
In the serum from which lipoids had been extracted, sufficient antibody remained in solution to protect all mice against 10-e cc. of culture, and to protect some mice against as much as 10-* cc. These results indicate that repeated absorption with homologous pneumococci does not entirely remove the protective antibody from antipneumococcus horse serum from which the lipoids have been extracted
Summary
This phenomenon has been termed the "prozone." Antipneumococcus rabbit serum, on the other hand, does not exhibit a similar result, but protects when comparable quantities are used. In confirmation of the prozone phenomenon with immune horse serum, the protocols of other workers demonstrate the failure of greater than optimal amounts of horse serum to protect (Yosioka (6), Felton (7) and Sobotka and Friedlgnder (8)). It has been repeatedly shown by Felton (9) that the immune globulin fraction of antipneumococcus horse serum is precipitated by tenfold dilution with distilled water.
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