Abstract
Lipogenesis by adipose tissue and liver from lean, genetic obese and control obese rats was studied in vitro. More palmitate-1- 14C was incorporated into lipid by adipose tissue of genetically obese rats than by control tissues. Glucose enhanced this effect but glycerol did not. Adipose tissue from genetic obese rats incorporated significantly more radioactivity from glycerol- 14C into glycerideglycerol than adipose tissue from hypothalamic-obese rats in the presence of glucose and epinephrine. In homogenates of fat from genetic obese rats the addition of glycerol-3-phosphate stimulated a greater rate of lipid synthesis than in homogenates from lesioned-obese rats.
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