Abstract
Lipocalin 2 (LCN2) is a 25 kDa protein found to be related to inflammatory modulation, cell-cell interaction, and clinical biomarker for acute renal injury. The LCN2 is highly expressed while the metastatic cancer cell invasion occurs and could be detected both in the urine or blood. Under overwhelmed inflammation, the progression of acute renal injury or cerebral ischemia could be aggravated and the serum level of LCN2 increased simultaneously. The neurological deterioration in subarachnoid hemorrhage (SAH) was closely related to neuroinflammation and inadequate microcirculation which might be LCN2 related as well. Here, the authors encourage further investigations to discover the prognostic correlation between LCN2 and SAH.
Highlights
Lipocalin 2 (LCN2) is a 25 kDa protein found to be related to inflammatory modulation, cell-cell interaction, and clinical biomarker for acute renal injury
Lipocalin 2 (LCN2), or neutrophil gelatinase associated lipocalin (NGAL), is a 25 kDa protein sharing general structure of lipocalin family with hydrophobic core, which facilitates its binding with lipophilic substances [3]
It was reported that NGAL prevents matrix metalloproteinase-9 (MMP)-9 from degradation [19], and in certain degree contributes to the tumor progression
Summary
Lipocalin 2 (LCN2) is a 25 kDa protein found to be related to inflammatory modulation, cell-cell interaction, and clinical biomarker for acute renal injury. The LCN2 is highly expressed while the metastatic cancer cell invasion occurs and could be detected both in the urine or blood. The progression of acute renal injury or cerebral ischemia could be aggravated and the serum level of LCN2 increased simultaneously.
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