Abstract
ObjectiveTo evaluate the effect of lipo-PGE1 on renal hypoxia in patients with DKD by BOLD-MRI. Materials and methodsAll patients were divided into DKD group and CKD-without-diabetes group. All patients received intravenous 10 μg lipo-PGE1 once daily for 14 days. BOLD-MRI was performed before and after lipo-PGE1 administration to acquire renal CR2* and MR2* values. ResultsRenal MR2* value in DKD group after lipo-PGE1 treatment were significantly decreased compared with the baseline. However, no significant differences in MR2* values were found in the CKD-without-diabetes group. ConclusionsLipo-PGE1 was shown to improve kidney medullary oxygenation in patients with DKD.
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