Abstract
Objective: To determine the effects of intraperitoneal Lipiodol™ and methylene blue in prevention of postsurgical adhesion formation. Study design: Thirty female rats were divided into three equal groups and a standard damage to provoke adhesion formation was made by laparotomy to each of them. Methylene blue and Lipiodol™ was administered intraperitoneally to the first and second groups, respectively; while the third group was taken as control and no additional intervention was made. Adhesions were scored by a second look laparotomy which was made 21 days after the first operation. Results: Adhesion scores of the second group (i.e. Lipiodol™ group) were significantly lower than that of controls. No significant differences were present between any other groups (i.e. methylene blue versus control and methylene blue versus Lipiodol™). Conclusion: Intraperitoneal administration of Lipiodol™ inhibits postsurgical adhesion formation in rats.
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