Abstract
The mitotic checkpoint, conserved from yeast to humans, delays the onset of anaphase until all chromosomes are aligned at the metaphase plate ensuring equal chromosome segregation. The RZZ complex, an essential mitotic checkpoint component present only in higher eukaryotes regulates checkpoint activation and silencing. Checkpoint activation occurs by RZZ mediated Mad1-Mad2 kinetochore recruitment whereas checkpoint silencing is by dynein/dynactin kinetochore recruitment through Spindly. Here we discuss recent developments in the mitotic checkpoint function of Spindly.
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