Lipidotransport system in patients with acne conglobata forms

Abstract

The lipidotransport system at conglobate acne as more severe form that characterized by pronounced hyperplasic and hypertrophic processes in sebaceous gland was studied. The study was based on the presence of relative hyperandrogenism in the pathogenesis of acne, due to the active synthesis of 5.alpha.-dihydrotestosterone sebocytes of sebaceous hair follicles of type III, and the fact that the predecessor of 5a-dihydrotestosterone is cholesterol. The study included 130 persons (60 women, 70 men) at the age of 17-36 years with acute stage of conglobate acne and disease duration from 3 months to 18 years. In addition 55 persons with papulopustule acne (23 women, 32 men) in similar age as control group were studied. A total cholesterol, LDL cholesterol, HDL cholesterol and triglycerides were determined by semi-automatic biochemical analyzer BTS-350 using the kits of the company Deacon (Moscow). An abdominal organs and retroperitoneal space (liver, gall bladder, and pancreas) were examined by ultrasound diagnostic. Lipid metabolism changes were revealed in patients with conglobate acne, and was not found in patients with papulopustule acne. This lipid changes were associated with a tendency to increase in triglycerides, total cholesterol, lowering LDL cholesterol in HDL cholesterol content. It’s noted that in papulopustule form were not registered a higher LDL cholesterol levels but in conglobate form this parameter were 7.69% patient. With increasing duration of the disease the concentration of triglycerides, total cholesterol, LDL cholesterol is rising, while lowering levels of HDL cholesterol at the development of chronic pancreatitis.