Abstract
Prolonged treatment of rats with the anorectic drug chlorphentermine or the tricyclic antidepressants iprindole and 1-chloro-amitriptyline caused the formation of numerous cytoplasmic inclusions in nerve cells of the cervical spinal cord and cerebellar cortex. The antidepressant drugs clomipramine, amitriptyline and noxiptiline had only weak or no effects. The abnormal, membrane-bound inclusions consisted either of parallel or concentrically arranged lamellae, or they exhibited crystalloid or reticular internal patterns. The alterations correspond to previous observations on extraneural tissues of drug-treated animals. According to a proposed concept, the present findings are interpreted to reflect a drug-induced lipidosis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
