Abstract

There are no comprehensive studies of lipid species in prostate cancer patients. In this study, global lipid profiles were determined in fresh‐frozen prostate tissues and plasma from prostate cancer patients and controls using electrospray tandem spectrometry (ESI‐MS/MS). In patients' plasma, 78 species increased concentrations >50% and 27 species decreased concentration >50% compared to controls' plasma. In cancer tissues, 56 species increased concentrations >50% and 12 species decreased concentration >50% compared to control tissues. Twenty‐two distinct lipid species in patients' plasma and 15 in cancer tissues were detected, which were absent in controls. Lipid concentrations were significantly different in 22 species between plasma from patients and controls and in 11 species between cancer and control tissues. Compared to controls, the lipid concentrations in patients' plasma increased in 8 of 11 head groups, while that in cancer tissues decreased in 8 of 10 head groups. All of 14 individual lipid species in Lysophosphatidylcholine were increased in both patients' plasma (1.7 times, p=0.025) and cancer tissues (1.33 times). Ceramide phosphorylethanolamine decreased significantly in cancer tissues (0.24 times, p=0.017). The results suggest that alterations in lipid could serve as new biomarkers for studying pathogenesis and monitoring progression of prostate cancer.

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