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Abstract
Lipidomics is defined as the analysis of lipids on the systems-level scale together with their interacting factors. In this review, we will discuss the technical developments in the field of lipidomics and overview the current state of the lipid bioinformatics field as well as suggest few potential new areas of research. The role of bioinformatics in the development of lipidomics will also be discussed.
Highlights
The word “lipidome” first appeared in the literature in 2001
There is a bioinformatics strategy for lipidomics analysis. It has been utilized the recently developed nomenclature of lipids to generate a diverse scaffold of lipid compounds represented by the Simplified Molecular Input Line Entry System (SMILES) representation each compound entry is linked to the available information on lipid pathways and contains the information that can be utilized for automated identification from high-throughput LC/MS-based lipidomics experiments [59,60]
The genetic equidistance result is the most remarkable result of molecular evolution since it was completely unexpected from classical Neo-Darwinian evolution theory [66]
Summary
The word “lipidome” first appeared in the literature in 2001. Lipidomics is an emerging field of biomedical research which includes complex lipidome analysis. Lipids are small molecules that share common physical and chemical properties as a class, whose presence and abundance are key to much of metabolic regulation, from subcellular compartments to whole body energy control and signaling. It is an emerging field in biomedical research. At the level of the cell, lipidomics must quantitatively describe all lipids and their functions. The molecular nature of individual entities of glycome and lipidome such as the carbohydrates and lipids is highly complex due to their diversity and perpetual metabolic flux in a biological system at either microsystem or macrosystem levels [4]. The main biological functions of lipids include: 1. Energy storage and structural components of cellular membranes
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