Abstract
IntroductionThe relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may provide new insights into the development of obesity.MethodsMass spectrometry coupled with liquid chromatography was applied to detect the global lipidome in the fasting plasma from 90 Chinese adolescents, including 34 obese adolescents, 26 overweight adolescents, and 30 adolescents with a normal body mass index (BMI). All participants underwent anthropometric measurements by using InBody. Clinical biochemical indicators were measured by Cobas Elecsys.ResultsBoth qualitative and quantitative analyses revealed a gradual change in plasma lipid features among obese students, exhibiting characteristics close to overweight students, but differing significantly from normal students. Compared with normal and overweight students, levels of triglyceride (TG), 18-hydroxycortisol, isohumulinone A, and 11-dihydro-12-norneoquassin were up-regulated in the obese group, while phosphatidylcholine (PC), phosphatidylethanolamine (PE), lysoPC (LPC), lysoPE (LPE), and phosphatidylinositol (PI) were significantly down-regulated in the obese group. Then, we conducted Venn diagrams and selected 8 significant metabolites from the 3 paired comparisons. Most of the selected features were significantly correlated with the anthropometric measurements.ConclusionsThis study demonstrated evidence for a relationship between the eight significant metabolites with obese adolescents. These lipid features may provide a basis for evaluating risk and monitoring the development of obesity.
Highlights
The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified
The increased prevalence of overweight and obesity in children and adolescents has been observed in several countries, and weight gain is an independent predictor for metabolic syndrome development, it is not seen in all obese individuals
Metabolic syndrome is defined as the presence of a combination of risk factors for cardiovascular disease and type 2 diabetes, including obesity, dyslipidemia, hypertension and glucose intolerance [4]
Summary
The relationship between dyslipidemia and obesity has been widely reported, but the global lipid profiles associated with the development of obesity still need to be clarified. An investigation into the association between the lipidomic plasma profile and adolescent obesity may provide new insights into the development of obesity. A high prevalence of obesity and metabolic syndrome can be observed in both adults and young people. These phenomena affect 380 million children and adolescents worldwide [1]. The increased prevalence of overweight and obesity in children and adolescents has been observed in several countries, and weight gain is an independent predictor for metabolic syndrome development, it is not seen in all obese individuals. The diagnosis of the possible presence of obesity at early ages, accompanied by control interventions, should have a favorable impact on the health of adult people and the prevention of cardiovascular outcomes
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