Abstract
BackgroundMigraine is a prevalent, disabling type of primary headache disorder associated with a high socioeconomic burden. The clinical management of migraine is challenging. This study was to identify potential serum lipidomic biomarkers of migraine.MethodsThe serum lipidomic profile of migraine sufferers was compared with healthy individuals using Liquid Chromatography coupled to Mass Spectrometry (LC-MS). Volcano plot analysis by Student’s t-test was performed to identify the differential metabolites. Receiver operating characteristic (ROC) curves were constructed and the area under ROC curves (AUC) was calculated to evaluate whether the metabolites could be efficiently exploited for constructing a sensitive biomarker of migraine.ResultsA total of 29 serum metabolites from 4 classes of lipids including acylcarnitines, non-alpha-hydroxy-sphingosine ceramides (Cer_NSs), lysophosphatidylcholines (lysoPCs) and lysophosphatidylethanolamines (lysoPEs) were significantly different in migraine patients and controls. Of note, Cer_NSs were significantly elevated and lysoPEs were significantly decreased in migraine patients. LysoPE 18:1, lysoPE 18:2 and lysoPE 22:5 were found to be decreased in both positive and negative ion mode. Moreover, except for lysoPC 20:0, other lysoPCs were decreased in migraine patients. ROC curve analysis indicated that lysoPC 16:0 and lysoPC 20:0 are potential sensitive and specific biomarkers for migraine.ConclusionLysoPC 16:0 and lysoPC 20:0 may be potential biomarkers for migraine. We suggest therapeutic management of these metabolites may be helpful in the prevention and treatment of migraine.
Highlights
Migraine is a prevalent, disabling type of primary headache disorder associated with a high socioeconomic burden
We aimed to examine serum lipidomic metabolites with Liquid Chromatography coupled to Mass Spectrometry (LC-MS) to identify potential migraine biomarkers which may provide useful fundamental information for the prevention and treatment of migraine
Identification of potential metabolic biomarkers Principal component analysis (PCA) score plots which include migraine patients, healthy controls and quality control (QC) samples are shown in Fig. 1a and 1D
Summary
Migraine is a prevalent, disabling type of primary headache disorder associated with a high socioeconomic burden. This study was to identify potential serum lipidomic biomarkers of migraine. Migraine is a common headache disorder with a lifetime prevalence of 13% in men and 33% in women [1]. In addition to genomics and proteomics, lipidomics have been employed as a metabolomic approach for investigation of the qualitative and quantitative profiles of lipid metabolites from serum, plasma, tissue, cells and organisms [6]. We aimed to examine serum lipidomic metabolites with Liquid Chromatography coupled to Mass Spectrometry (LC-MS) to identify potential migraine biomarkers which may provide useful fundamental information for the prevention and treatment of migraine
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