Abstract
Endometriosis is an estrogen-dependent chronic inflammatory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. The heterogeneity of the disease makes accurate diagnosis and treatment a clinical challenge. In this study, we generated two models of endometriosis: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs) derived from the lesion tissues of endometriosis patients. We then applied resveratrol to assess its therapeutic potential. Resveratrol intervention had significant efficacy to attenuate lesion size and to rectify aberrant lipid profiles of model rats. Lipidomic analysis revealed significant lipidomic alterations, including notable increases of sphingolipids and decreases of both glycerolipids and most phospholipids. Upon resveratrol application, both proliferation capacity and invasiveness parameters decreased, and the early apoptosis proportion increased for HEcESCs. The activation of PPARα was also noted as a factor potentially contributing to recovery from endometriosis in both models. Our study provides valuable insight into the mechanisms of resveratrol in endometriosis and therefore strengthens the potential for optimizing resveratrol treatment for this disease.
Highlights
IntroductionEndometriosis (EMs) is a refractory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility
To explore the mechanisms associated with the development of endometriosis and the effects of resveratrol on the treatment of this disease, we generated two models: the first in rats and the second using human ectopic endometrial stromal cells (HEcESCs)
Women with endometriosis often suffer from severe pelvic pain, resulting in significantly decreased quality of life and high costs for the healthcare system [1, 34]
Summary
Endometriosis (EMs) is a refractory disease that affects approximately 10% of women of reproductive age and up to 50% of women with infertility. It is associated with functional endometrial glands and stroma implantation outside the uterus. Women with EMs often suffer from severe pelvic pain, resulting in significantly decreased quality of life and high costs for the healthcare system [1]. Available treatments include surgery and hormone medication, both of which have many unpleasant side effects and a high rate of relapse beyond their completion [2, 3]. Searching for new and long-term effective treatment for endometriosis is of great significance. Resveratrol (trans-3,5,4′-trihydroxystilbene), a phytoalexin polyphenol found in natural plants or fruits, has previously been highlighted as a potential supplement for the treatment of cancers, cardiovascular disease, and EMs
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