Abstract
The effect of Pediococcus acidilactici M76 (lactic acid bacteria) isolated from makgeolli on mice fed a high fat diet was investigated to clarify the lipid lowering function. C57BL/6J male mice were randomly divided into a normal diet (ND) group, high fat diet (HD) group, HD plus Pediococcus acidilactici DSM 20284 reference strain (PR) group, and HD plus Pediococcus acidilactici M76 strain (PA) groups. The lyophilized PA and PR strain were dissolved in distilled water at a final concentration of 1.25 × 109 cfu/mL and was given orally to animals at a dose of 4 mL/kg body weight for 12 weeks. The PA group had a lower final body weight, adipose tissue weight, and lipid profile than those in the HD group. Additionally, level of ACC, FAS and PPAR-γ, a key lipid synthesis enzyme, was markedly suppressed in the PA compared to those in the HD group. These data suggest that P. acidilactici M76 may exert a lipid-lowering effect in high fat diet- induced obese mice.
Highlights
Obesity is a medical condition characterized by accumulation of excess body fat
C57BL/6J mice fed a high fat diet by examining changes in serum and liver lipid profiles and changes in hepatic mRNA levels of enzymes involved in lipid metabolism
C57BL/6J mice fed with high fat diet for 12 weeks became obese associated with both increased body weight and epididymal fat
Summary
Obesity is a medical condition characterized by accumulation of excess body fat. In Asia, increased consumption of energy dense food over the past decade has occurred both in urban and rural populations [1]. Medical costs for the obesity related diseases have increased from day to day, and the effort to decrease the percentage of body fat has become a worldwide interest. Makgeolli contains essential amino acids, proteins, sugars, live yeast, and lactic acid bacteria (LAB) because the fermented product remains unfiltered. It has unique nutritional characteristics [4,5]. The major LAB identified in makgeolli is Lactobacillus sp. LAB used in various fermented food have therapeutic effects on human health, and their consumption has resulted in improvements of hepatic disease, allergies, hypertension, cancer, blood cholesterol and hyperlipidaemia [11,12]. C57BL/6J mice fed a high fat diet by examining changes in serum and liver lipid profiles and changes in hepatic mRNA levels of enzymes involved in lipid metabolism
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