Abstract
The enzymatically labile peptidcs LHRH and TRH were conjugated to various lipidic peptides. The conjugates and free peptides were incubated with Caco-2 cell homogenates and their respective degradation profiles were studied following incubation. Conjugation to lipidic peptides increased the half-life of LHRH and TRH. The Caco-2 cell homogenates were capable of cleaving the conjugated lipidic peptide, to release the parent LHRH or TRH. The released LHRH or TRH subsequently demonstrated a longer half-life than when present alone in the incubation mixture, suggesting that the cleaved lipidic peptide is capable of inhibiting enzymes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
