Abstract
Soluble Curcumin: A Promising Oral Supplement For Health ManagementPuneet Gandhi, Zeba Khan, Nivedita Chakraverty
Highlights
Phenytoin was first introduced in 1938 as an antiepileptic agent as the first-line therapeutic approach for various generalized convulsive disorders
It was found that lipid nano-emulgel demonstrated the highest release rate of phenytoin, with 93.12% drug released in 12 hours, followed by cream-gel with 56.42% and macro-emulgel with 51.51%
Physicochemical properties of lipid emulsions Three oil-in-water (O/W) coconut kernel oil (CKO)/soybean oil (SBO) emulsions, namely nano-emulsion, macro-emulsion and cream were formulated with the same ingredients as listed in Table 1 but differed in droplet size
Summary
Phenytoin was first introduced in 1938 as an antiepileptic agent as the first-line therapeutic approach for various generalized convulsive disorders. Many studies showed that 50% of the patients receiving long-term oral phenytoin treatment were presented with a side effect of gingival hyperplasia (Shaw et al, 2007). This apparent stimulatory effect on the connective tissues suggested that phenytoin has wound healing effect (Simsek et al, 2014; Spaia, 2004). Mixed lipid phase composed of both MCT and LCT was expected to have better physicochemical properties in preparing the LBDDS formulations for this study. The storage stability, rheological properties and release kinetics of each formulation system were evaluated to assess their suitability as drug delivery formulations for topical phenytoin
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