Abstract
Background Lipid transfer proteins (LTP) are considered true food allergens because sensitization takes place in the gastrointestinal tract, in contrast with other food allergens like profilins or Bet v 1-homologues, where sensitization is a consequence of an allergic sensitization to inhaled allergens. Although allergy to peach LTP (pru p 3) is frequently associated to sensitization to plane tree pollen LTP (Pla a 3) and/or mugwort LTP (Art v 3), it has never been elucidated if this cross-reactivity could lead to a respiratory allergy. The aim of this study is to demonstrate that a LTP-dependent food allergy with the adequate exposure can induce a LTP-dependent respiratory allergy.
Highlights
Lipid transfer protein: a link between food and respiratory allergy
Lipid transfer proteins (LTP) are considered true food allergens because sensitization takes place in the gastrointestinal tract, in contrast with other food allergens like profilins or Bet v 1-homologues, where sensitization is a consequence of an allergic sensitization to inhaled allergens
The aim of this study is to demonstrate that a LTP-dependent food allergy with the adequate exposure can induce a LTP-dependent respiratory allergy
Summary
Lipid transfer protein: a link between food and respiratory allergy Background Lipid transfer proteins (LTP) are considered true food allergens because sensitization takes place in the gastrointestinal tract, in contrast with other food allergens like profilins or Bet v 1-homologues, where sensitization is a consequence of an allergic sensitization to inhaled allergens. Allergy to peach LTP (pru p 3) is frequently associated to sensitization to plane tree pollen LTP (Pla a 3) and/or mugwort LTP (Art v 3), it has never been elucidated if this cross-reactivity could lead to a respiratory allergy.
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