Abstract
Transport vesicles that bud from one cell membrane must change identity before fusing with another. During the process of clathrin-mediated endocytosis, various lipid phosphates mediate this identity change. See Letter p.233 Phosphoinositides are important regulators of intracellular membrane traffic. Although the role of phosphatidylinositol-4,5-bisphosphate has been well characterized, that of phosphatidylinositol-3,4-bisphosphate (PI(3,4)P2) remains unclear. In this study, Volker Haucke and colleagues show that formation of PI(3,4)P2 by the class II phosphatidylinositol-3-kinase C2α (PI(3)K C2α) enzyme spatiotemporally controls clathrin-mediated endocytosis. These findings present a novel function of PI(3,4)P2 in membrane traffic.
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