Abstract
The activity of the plasma lecithin:cholesterol acyltransferase (LCAT) was studied in control subjects and in two groups of patients with liver diseases (cholestasis or cirrhosis). Polyunsaturated phosphatidylcholine (PU-PC), as a special substrate, was administered to all subjects by single intravenous infusion of 3g. Before and after infusion the transesterification rate was assayed by three different methods: 1) assay according to Glomset & Wright (7) using plasma against a standard substrate, 2) assay of pooled plasma of normal subjects against substrate prepared from the plasma of the patients, and 3) assay according to Stokke & Norum (24). In normal subjects, no statistically significant differences of the enzyme activity levels were observed before PU-PC infusion. There was a tendency to lower LCAT activity in patients with liver disease compared with normal subjects before PU-PC infusion. After PU-PC infusion a significant increase of LCAT activity was observed with methods 2) and 3) in patients w...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
