Abstract
Lipid-rich carcinomas occurred in seven female dogs. Affected dogs were purebred (all but one), intact (all but one), and between 4 and 13 years of age. Five of them had a history of parity, one had pseudopregnancy, and none had received contraceptive steroids. The tumors were single (five cases) or multiple (two cases) well-circumscribed masses of different sizes (varying from 1 to 6 cm in diameter), composed of solid nests and cords of tumor cells separated by a moderate amount of stroma. The tumor cells contained either multiple and small or large and solitary vacuoles that pushed the nucleus to the periphery of the cell (signet-ring cell). A glandular epithelial immunophenotype (cytokeratins 5 and 8 and 8 and 18) was observed in the majority of tumor cells. All tumors lacked both estrogen and progesterone receptors, and five out of seven tumors gave rise to local recurrence and proximal or distant metastases or both.
Highlights
Lipid-rich carcinomas occurred in seven female dogs
Lipid-rich carcinoma is a mammary carcinoma characterized by cells with abundant vacuolated cytoplasm that contains a large amount of neutral lipid.[10]
Normal canine tissues known to contain the antigens sought were used as external positive controls as follows: canine skin for cytokeratins 5 and 8, cytokeratins 8 and 18 (NCL-5D3; glandular epithelium), cytokeratin 14, actin (HHF 35; muscle), calponin, and vimentin antibodies; and canine uterus for estrogen and progesterone receptor antibodies
Summary
Lipid-rich carcinomas occurred in seven female dogs. Affected dogs were purebred (all but one), intact (all but one), and between 4 and 13 years of age. Metastases to the right superficial lymph node lead to total mastectomy, and a tumor in R3 (1-cm Ø) was found. A great amount of neutral lipid was identified in the cytoplasm of the tumor cells by Oil Red O stain on frozen material from a recurrence in dog no.
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