Abstract
BackgroundWe investigated relationship of low levels of high density lipoprotein cholesterol (HDL-C), high levels of triglycerides, and renal function for the odds, prognosis and survival following acute coronary events among patients with a first event and normal low density lipoprotein cholesterol levels.ResultsA case-control study based on 557 patients and 1086 matched control subjects was conducted. Case patients were followed up for survival with a median of 1.9 years. Participants in the higher quintiles of HDL-C had lower odds to develop acute coronary events (the adjusted odds ratios were 0.24 for the second, 0.24 for the third, 0.10 for the fourth and 0.05 for the fifth quintile). Patients with normal glomerular filtration rate were at a lower risk for all-cause death. However, a reverse association between triglycerides and death risk was found: patients with higher triglycerides were at a lower risk for all-cause death (adjusted relative risk, 0.38 for triglycerides ranging from 82 to 132.9 mg/dL, and 0.14 for triglycerides > = 133 mg/dL).ConclusionsLow HDL-C was significantly associated with acute coronary events, and triglyceride levels as well as renal function were inversely related to all-cause deaths after the coronary event.
Highlights
Lipid-related residual risk, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglycerides, has become a clinical target since the availability of aggressive low density lipoprotein cholesterol (LDL-C) lowering by statin treatment [1,2,3,4]
We investigated associations between low HDL-C, high triglycerides, and renal function status, for odds for coronary events among patients who had suffered from first events and were within normal LDL-C levels in this retrospective case control study, matching for age, sex, and LDL-C levels
Compared with the matched control subjects, the case patients were more likely to be hypertensive, smokers, and more likely to have a history of diabetes, stroke, advanced chronic kidney disease and a higher age, systolic blood pressure, serum creatinine and estimated glomerular filtration rates
Summary
Lipid-related residual risk, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglycerides, has become a clinical target since the availability of aggressive low density lipoprotein cholesterol (LDL-C) lowering by statin treatment [1,2,3,4]. A substantial incremental risk for further cardiovascular events was still apparent even in patients with LDL-C levels less than 70 mg/dL who had high triglycerides and low HDL-C [7,8]. We investigated relationship of low levels of high density lipoprotein cholesterol (HDL-C), high levels of triglycerides, and renal function for the odds, prognosis and survival following acute coronary events among patients with a first event and normal low density lipoprotein cholesterol levels
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