Abstract
The role of lipid rafts in T cell signalling has recently been extensively studied and hotly debated. In this review we wish to present recent advances in the study of lipid rafts with regards to the initiation of TCR signal transduction. We also wish to clarify some common misconceptions regarding certain models and experimental methods reported in the literature. Based on the relevant data supporting the functional importance of lipid rafts in early TCR mediated signalling events, we propose a model for TCR signal initiation involving a “TCR signalosome” organized in a specific raft subset, which is highly dynamic and evolving upon TCR activation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
