Lipid profile of childhood cancer survivors and the effects of vitamin D supplementation: a prospective study

Shaimaa Kandil,Ashraf Fouda,Yasmin Salama,Suzy Abdelmabood,Khadijah Boujettif

doi:10.1186/s43054-021-00051-5

Abstract

BackgroundChildhood cancer survivors (CCS) have high prevalence of obesity vitamin D (VD) deficiency together with dyslipidemia. We aimed to evaluate lipid profile and the effect of VD supplementation in CCS.ResultsVD deficiency was more frequent among obese CCS and their lipid profiles, TC, and LDL-C levels were significantly higher compared to non-obese patients. After VD supplementation trials, VD levels increased among obese and non-obese children albeit it was significantly higher in non-obese subjects while the lipid profile of obese patients significantly decreased. Also, parathyroid hormone levels were persistently elevated among VD-deficient obese patients. Yet, the weight of obese patients remained unchanged.ConclusionVD deficiency was more prevalent among obese CCS. VD supplementation helped in normalization of the lipid profile of obese CCS. Regular measurement of PTH and 25OH-VD is recommended for CCS especially obese ones who may need VD supplementation.

Highlights

Childhood cancer survivors (CCS) have high prevalence of obesity vitamin D (VD) deficiency together with dyslipidemia
Obese patient’s lipid profiles, Total cholesterol (TC), and lowdensity lipoprotein-cholesterol (LDL-C) levels were significantly higher compared to non-obese patients
We evaluated in this study the lipid profile, prevalence of VD deficiency and the effect of VD supplementation among CCS, and the overall effects of the 6-month VD supplementation on their VD levels, weight status, and lipid profiles

Summary

Introduction

Childhood cancer survivors (CCS) have high prevalence of obesity vitamin D (VD) deficiency together with dyslipidemia. One of the complications of cancer therapy for children and adolescents is obesity, which is a risk factor for the development of adulthood dyslipidemia [1]. This is explained by positive energy balance because of overconsumption of food calories and decreased physical activity [2]. Previous researches found that VD status index serum 25-hydroxy vitamin D (25OH-VD) tends to be lower among obese adults [4, 5] and obese children [6].

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