Abstract
BackgroundChanges in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. This study evaluated the alterations in extended lipid profile in untreated patients of oral submucous fibrosis (OSMF) and studied the correlation between lipid levels with tobacco consumption.Materials and methodsIn this hospital-based study, 65 clinically diagnosed and histopathologically proven patients of OSMF and 42 age and sex matched controls were studied. In these samples serum lipids including: (i) Total cholesterol, (ii) LDL cholesterol (LDLC), (iii) HDL cholesterol (HDLC) (iv) VLDL cholesterol (VLDLC) (v) triglycerides (vi) Apo-A1 (viii) Apo-B and (viii) LPa were analyzed.ResultsA significant decrease in plasma total cholesterol, HDLC and Apo-A1 was observed in patients with OSMF as compared to the controls. Thus an inverse relationship between plasma lipid levels and patients was found in OSMF.ConclusionThe lower levels of plasma cholesterol and other lipid constituents in patients might be due to their increased utilization. The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions.
Highlights
Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity
The findings strongly warrant an in-depth study of alterations in plasma lipid profile in patients with oral precancerous conditions
Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity, which is characterized by an epithelial and subepithelial inflammatory reaction followed by fibroelastic changes in the submucosa [1]
Summary
Changes in lipid profile have long been associated with malignancies as lipids play a key role in maintenance of cell integrity. Oral submucous fibrosis (OSMF) is a chronic disease of the oral cavity, which is characterized by an epithelial and subepithelial inflammatory reaction followed by fibroelastic changes in the submucosa [1]. This disease occurs most commonly in South East Asia but cases have been reported worldwide in countries like Kenya, China, UK, Saudi Arabia and other parts of the world [2]. Again from Allahabad, confirmed that dohra/paan masala containing areca nut is a major risk factor of OSMF, especially in the younger age group.
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