Abstract
Background: To study the derangement of serum lipid profile in children 2 to 12 years with nephrotic syndrome. Methods: 50 children 2 to 12 years with nephrotic syndrome were identified. Patients were classified as remission, relapse and newly diagnosed. Lipid Profile was measured. Patients were followed-up after 4 weeks of steroid therapy. Results: Out of all the 50 subjects screened, 25 (50%) subjects had high total cholesterol, 26 (52%) had high triglyceride, 8 (16%) had abnormal HDL cholesterol and 25 (50%) had high LDL cholesterol. After 4 weeks of steroid therapy though there was significant reduction in lipid components. Conclusion: Our study shows that in nephrotic syndrome, there is generalised hyperlipidemia and hypoalbuminemia. Serum cholesterol, triglycerides and LDL cholesterol were deranged in almost all subjects. In cases in relapse after 4 weeks of steroid therapy there is persistent raised total cholesterol, triglycerides and LDL cholesterol, which may predispose to the development of atherosclerosis in near future.
Highlights
Nephrotic syndrome is primarily a paediatric disorder and is 15 times more common in children than adults
The raised levels of various lipid parameters, frequent relapsers, steroid resistant nephrotic syndrome and children with hypertension concomitantly predispose these children for increased risk of atherosclerosis and thrombosis in future
Our study shows that in nephrotic syndrome, there is generalised hyperlipidemia and hypoalbuminemia
Summary
Nephrotic syndrome is primarily a paediatric disorder and is 15 times more common in children than adults. Hyperlipidemia is usually observed during the active phase of the disease and disappears with resolution of proteinuria. It may persist in some cases, leading to increase risk of atherosclerosis in later life and development of progressive renal injury [2]. Hyperlipidemia is not always connected with nephrotic disease activity and may sometimes persist for long time, especially in frequently relapsing nephrotic syndrome. To study the derangement of serum lipid profile in children 2 to 12 years with nephrotic syndrome. In cases in relapse after 4 weeks of steroid therapy there is persistent raised total cholesterol, triglycerides and LDL cholesterol, which may predispose to the development of atherosclerosis in near future
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