Abstract
Aim: To assess the lipid profile and vitamin B12 levels in women having gestational diabetes mellitus.
 Study Design: Case Control study.
 Place and Duration: Department of Biochemistry and Gynecology/Obstetrics LUMHS Hospital Jamshoro total 1 year duration from January 2018 to December 2018.
 Methodology: A sample of 291 pregnant women was grouped as; 216 diagnosed gestational diabetes mellitus (GDM) and 75 non gestational diabetes mellitus were selected according to criteria. Sera were evaluated for glucose (hexokinase method), blood lipids and Vitamin B12 (ECLIA assay method) by Cobas chemistry analyzer. Triglyceride/high density lipoprotein (TAGs/HDLc) ratio was calculated as log of transformed TAGs to HDLc. TAGs/HDLc ratio was labelled as low risk (0.3 – 0.1), medium risk (0.1 – 0.24) and high risk (>0.24). Statistical SPSS software 21.0 (IBM, Inc USA) was used to analyze the research variables at 95% CI (P ≤ 0.05).
 Results: Age of cases was 37.9±5.19 years (P=0.051). Fasting and random blood glucose levels were elevated significantly (P=0.0001). Vitamin B12 in cases was low noted as 155.6±71.3 ng/mL compared to 251.5±33.1 in control (P=0.0001). Any type of vitamin B12 deficiency was present in 153 (70.51%) GDM cases compared to 37 (49.4%) control (P=0.0001). Low, medium and high atherogenicity risk was found in 56.01%, 37.5% and 6.4% GDM cases and 50.5%, 36.6% and 0% in control respectively (P=0.0001).
 Conclusion: It was found in the present study that triglyceride to HDLc ratio was found elevated in Gestational Diabetes mellitus women with vitamin B12 deficiency.
Highlights
Gestational diabetes mellitus (GDM) is a metabolic disorder of high blood glucose levels first time diagnosed during pregnancy
Any type of vitamin B12 deficiency was present in 153 (70.51%) GDM cases compared to 37 (49.4%) in control cases (P=0.0001)
We found any type of vitamin B12 deficiency was present in 153 (70.51%) GDM cases compared to 37 (49.4%) in control (P=0.0001)
Summary
Gestational diabetes mellitus (GDM) is a metabolic disorder of high blood glucose levels first time diagnosed during pregnancy. It is a state of glucose intolerance noted during pregnancy without prior history of diabetes mellitus (DM) [1]. Pregnant women may develop hyperglycemia and glycosuria during initial period of gestation. True prevalence of GDM is unknown in developing countries including Pakistan because of lack of hospital registries and incomplete records. Global prevalence of GDM is reported as 1 – 14 % [2]. 7% of pregnant women develop some degree of glucose intolerance that may be severe enough to develop GDM. Global burden of GDM was proposed as >200,000 cases [2]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
