Lipid profile and total bone mineral content in an experimental model of nutritional hypercholesterolemia

Abstract

Studies showed a strong relationship between fat diets and CVD but not, cholesterol levels involving bone health.Objective: to investigate in an experimental model of nutritional hypercholesterolemia, the association between lipid profile and total bone mineral content (BMC) under high‐oleic‐acid sunflower oil (HOSO) and sunflower oil (SO) diets. Weaning male Wistar rats (n=56) were randomly assigned to one of 7 groups: a) control group (C) or b) six experimental (E 1–6) for 6 wk. C received rodent diet for 6 wk. E were fed a high cholesterol diet (HCD) (pellets+biliary salts+colesterin+butter) for 3 wk (stage 1), followed by stage 2: E1, E3, E6 replaced the HCD by HOSO, SO or pellets, respectively. E2, E4: replaced butter by HOSO or SO, respectively. E5 was kept on HCD. After 6 wk, blood was drawn for cholesterol (CHO, mg/dl), triglycerides (TG, mg/dl), high density lipoprotein‐cholesterol (HDL‐CHO), HDL‐non‐cholesterol (N‐HDL‐CHO) and N‐HDL/HDL ratios. BMC by DXA (Lunar DPX‐L) was measured. Pearson's correlation coefficients were calculated, p was set at 5%.Results: the correlation between lipid profile vs. BMC were: +0.18 (ns), ‐0.65 (p<0.0001), −0.66 (p<0.0001), +0.32 (p<0.01) and −0.65 (p<0.0001) for TG, CHO, N‐HDL, HDL‐CHO and N‐HDL/HDL, respectively.Conclusion: there is a strong relationship between atherogenic lipid profile and bone formation. Awarded by UBACyT O 003–004