Abstract
BackgroundThis meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD).MethodsThe PubMed, Embase, and Cochrane Library electronic databases were systematically searched for prospective cohort study published through December 2019, and the pooled results were calculated using the random-effects model.ResultsTwenty-one studies with a total of 76,221 patients with CHD met the inclusion criteria. The per standard deviation (SD) increase in triglyceride was associated with a reduced risk of major adverse cardiovascular events (MACE). Furthermore, the per SD increase in high-density lipoprotein cholesterol (HDL-C) was associated with a reduced risk of cardiac death, whereas patients with lower HDL-C were associated with an increased risk of MACE, all-cause mortality, and cardiac death. Finally, the risk of MACE was significantly increased in patients with CHD with high lipoprotein(a) levels.ConclusionsThe results of this study suggested that lipid profile variables could predict major cardiovascular outcomes and all-cause mortality in patients with CHD.
Highlights
This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD)
A total of 87 studies were selected for further evaluation, and 21 prospective cohort studies with a total of 76,221 patients with CHD were selected for the final meta-analysis (Fig. 1) [19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39]
The current study indicated that in patients with CHD, low total cholesterol (TC) was not associated with the risk of major adverse cardiovascular events (MACE) and cardiac death
Summary
This meta-analysis based on prospective cohort studies aimed to evaluate the associations of lipid profiles with the risk of major adverse cardiovascular outcomes in patients with coronary heart disease (CHD). Cardiovascular disease (CVD) is the leading cause of morbidity and mortality worldwide, accounting for nearly 30% of the total deaths based on the World Health Organization (WHO) statistics. Increases in triglyceride (TG) and total cholesterol (TC) levels could affect the constriction and abstraction of vessels in the heart, which are significantly correlated with the risk of CVD [5]. Increases in the low-density lipoprotein cholesterol (LDL-C) level could induce arteriosclerosis owing to accumulation of LDL-C in the intima-media of the artery, which could promote thrombocytopoiesis [6]. The CVD risk might be reduced in persons with increased high-density lipoprotein
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