Abstract
AbstractPeroxides, including lipid peroxides, with heme catalysts cause the binding of C14‐acetylaminofluorene to DNA if microsomes are present. This binding was 96% inhibited by paraoxon, a deacetylase inhibitor. It is concluded that peroxide‐peroxidase systems rapidly oxidize acetylated arylamines to proximate carcinogens following deacetylation by microsomal deacetylases. The DNA binding observed was greater than that observed with the liver microsomal mixed function oxidase catalyzed activation to N‐OH‐acetylaminofluorene, which binds to DNA following deacetylation by microsomal deacetylase. Lipid peroxidation or prostaglandin synthesis should therefore enhance carcinogenesis induced by arylamides.
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