Lipid peroxidation, serum iron and some antioxidants activities in pregnant women infected with HIV and malaria

Abstract

ABSTRACT This study determined the effects of malaria parasite and HIV infection on malondialdehyde (MDA), serum iron (Fe) and some enzymes activities of pregnant women in Abeokuta, Ogun State. A total of 251 pregnant women were enrolled for the study. Blood samples were collected from each consented pregnant women during ante-natal clinic for malaria test, HIV screening, MDA, Fe, gluthathione-S-transferases (GST), superoxides-dismutase (SOD) and peroxidase (PERO). The prevalence of malaria parasite infection and HIV in the study was 28.3% and 16.4%, respectively, while co-infection occurred in 8% of the population. Malaria prevalence increased with decrease in CD4 count. Though, HIV and malaria as single infection increased MDA and reduced serum iron values in the pregnant women (p < 0.05), MDA values were significantly higher (p < 0.05) in pregnant women with HIV and malaria co-infection. Reduction in SOD value was recorded in those with malaria and HIV co-infection but increased in other groups (p < 0.05). Serum PERO titer value in pregnant women with HIV and malaria co-infection was significantly lower (p < 0.05) compared with pregnant women infected with either HIV or Malaria. These results showed varying degrees of HIV and malaria-related oxidative stress in pregnant women.