Abstract

e17036 Background: The purpose of the study was to analyze neoadjuvant chemotherapy (NACT) effect on parameters of monoaminergic, free radical and hydrolytic systems in tissues of malignant ovarian tumors. Methods: Activity of parameters of monoaminergic, free radical and hydrolytic systems was determined in ovarian tissue of 92 patients with ovarian cancer. Tissues of tumorous and contralateral (non-tumorous) ovaries were studied, and results were compared to the data in 30 patients with uterine fibroids and other benign tumors. Results: Tumorous ovaries showed the decrease in vitamins E and A by 2.6 and 4.1 times, respectively, compared to the norm. The levels in contralateral ovaries were 5 and 2.8 times lower than the norm, respectively. SOD in tumor tissue exceeded the norm by 46%. Content of copper-zinc-SOD amounted to 15.7% of the total activity in healthy ovaries, while in tumorous ones – 8.2%. Diene conjugates in tumors were increased by 42% compared to the healthy ovaries. Contralateral ovaries showed 2.1 times increase in SOD activity compared to the norm; catalase activity was decreased by 35% which was similar to the value in tumor tissue. Diene conjugates in contralateral ovaries were increased by 38% compared to the healthy ovaries and did not differ from the value in tumor. MDA level was decreased by 4.1 times and did not differ from the value in tumor. Tumorous ovaries after NACT showed an increase in vitamins A and E by 1.8 and 3.2 times, respectively, compared to the levels before treatment; copper-zinc-SOD activity increased by 40.3%. Lipid peroxidation changed as well: diene conjugates level increased by 24.7% and MDA decreased by 47.7% compared to the values before treatment. Levels of the main antioxidant enzymes – SOD and catalase – in contralateral ovaries after NACT were similar to the normal ones; diene conjugates were close to the norm, vitamin E decreased by 40%, vitamin A – by 30%, MDA content did not change. Conclusions: Morphologically healthy tissue of the contralateral ovary in the organism affected by malignant tumor demonstrates signs of imbalance in antioxidant factors similar to those in the tumorous ovary. NACT results in normalization of metabolism indices in both tumorous and contralateral ovaries.

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