Lipid Peroxidation in Subretinal Fluid: Some Light on the Prognosis Factors.

Francisco Bosch-Morell,Enrique García-Gen,Salvador Mérida,Carmen Desco,Amparo Navea,Mariola Penadés

doi:10.3390/biom11040514

Abstract

The aim of this study was to identify a relation between the clinical characteristics and differences in lipid peroxidation in the subretinal fluid (SRF) of rhegmatogenous retinal detached patients by malondialdehyde (MDA) quantification. We collected 65 SRF samples from consecutive patients during scleral buckling surgery in rhegmatogenous retinal detachment (RRD) eyes. In addition to a complete ophthalmic evaluation, we studied the refractive status, evolution time, and the number of detached retinal quadrants to establish the extension of RRD. We studied the clinical aspects and oxidative stress and compared the characteristics among groups. We found that neither the evolution time of RRD nor the patients’ age correlated with the MDA concentration in the SRF. The MDA and the protein content of the SRF increased in the patients with high myopia and with more extended RRD. Our results suggest that oxidative imbalance was important in more extended retinal detachment (RD) and in myopic eyes and should be taken into account in the managing of these cases.

Highlights

Rhegmatogenous retinal detachment (RRD) is a severe and relatively frequent pathology
We studied a series of consecutive patients with rhegmatogenous retinal detachment (RRD) who underwent extraocular retinal detachment surgery in our clinic
We studied 65 eyes from 65 patients (41 men and 24 women) aged 59.2 ± 11.1 years

Summary

Introduction

Rhegmatogenous retinal detachment (RRD) is a severe and relatively frequent pathology. Its incidence is about one per 10,000 people yearly [1]; myopia increases the danger of detachment by 10-fold. One possible reason for this is that myopia leads to earlier vitreous liquefaction [2]. Oxidative damage is a well-known mechanism of apoptosis induction. Both have been frequently founded in ocular diseases [6]. The vitreous humor of patients with retinal detachment has oxidative products in it [7,8], not with lipid peroxidation products (LPO), which have demonstrated highly toxic activity [9,10]. The nature of the subretinal fluid (SRF) present in RRD has not been thoroughly studied

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