LIPID PEROXIDATION AND ANTIOXIDANT DEFENSE SYSTEM IN MENOPAUSAL WOMEN OF DIFFERENT ETHNIC GROUPS

Abstract

Aim: Сomparative assessment of lipid peroxidation - antioxidant defense parameters in Caucasian and Asian women in peri- and postmenopause. Methods: Altogether, 146 women of Caucasian (Russians (n = 82)) and Asian (Buryats (n = 64)) origins participated in the prospective non-randomized study. Each ethnic group was divided into three subgroups - women of reproductive age, perimeno-pause, postmenopause according to the gynecological status. The lipid peroxidation - antioxidant defense parameters were determined by spectrophotometric methods. Non-parametric tests were used for comparisons of the three independent groups. Results: in Russian perimenopausal women compared to women of reproductive age, an increase of lipid peroxidation substrates by 1.27 times (p = 0.032), active products of thiobarbituric acid (TBARS) by 1.25 times (p = 0.041), oxidized glutathione by 1.33 times (p = 0.021) levels and decrease of ketodienes and conjugated trienes (KD-CT) by 1.85 times (p < 0.001), retinol by 1.32 times (p = 0.043) levels, followed by an increase of KD-CT levels by 2 times (p < 0.001) and decrease of TBARS by 1.28 times (p = 0.042), а-tocopherol by 1.37 times (p = 0.001), retinol by 1.14 times (p = 0.019), GSSG by 1.16 times (p = 0.044) levels in postmenopausal women. In perimenopausal representatives of the Buryat ethnos compared with women of reproductive age, an decrease of lipid peroxidation substrates by 1.66 times (p < 0.001), conjugated dienes (CD) by 2.41 times (p < 0.001), KD-CT by 1.53 times (p = 0.045), а-tocopherol by 1.64 times (p < 0.001), retinol by 1.20 times (p = 0.024) levels, followed by an increase of lipid peroxidation substrates by 1.31 times (p = 0.028), CD by 1.53 times (p = 0.008), KD-CT by 1.32 times (p = 0.032) levels in postmenopausal women. Conclusions: Our results suggest that oxidative stress in menopause is more pronounced in Caucasian than in Asian women.