Abstract
The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.
Highlights
Skin diseases cause significant discomfort to millions of people around the world daily
This review focuses on the recent advances of lipid-based nanosystems in the treatment of skin disorders
nanostructured lipid carriers (NLC) are considered to be an improved variety of Solid lipid nanoparticles (SLN), holding the same unique properties, but with an optimized core composition, resulting in a higher drug loading capacity, better stability, and ability to act at lower temperatures
Summary
Skin diseases cause significant discomfort to millions of people around the world daily. The success of topical treatment of skin diseases requires a timely, accurate diagnosis, as well as an effective, simple, and not very invasive targeted topical treatment It depends on the type of dosage form (the type of delivery system used to supply the drug to the skin) and the application method [6]. The outermost sublayer of the epidermis, named stratum corneum (SC) (10–20 μm), plays a fundamental role as the body’s first and main physical skin barrier from external menaces [19,20,21]. It consists of of corneocytes—specific cells that areare thethe essential limiting menaces. Formation, with anan extracellular matrix of of lamellar membranes [23]
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