Abstract
Rheumatic diseases are a group of chronic autoimmune disorders that involve multiple organs or systems and have high mortality. The mechanisms of these diseases are still ill-defined, and targeted therapeutic strategies are still challenging for physicians. Recent research indicates that cell metabolism plays important roles in the pathogenesis of rheumatic diseases. In this review, we mainly focus on lipid metabolism profiles (dyslipidaemia, fatty acid metabolism) and mechanisms in rheumatic diseases and discuss potential clinical applications based on lipid metabolism profiles.
Highlights
Rheumatic diseases are a group of chronic heterogeneous autoimmune disorders that involve multiple organs or systems and cause high mortality and disability
Immunometabolism has been widely studied in autoimmune and rheumatic diseases, and studies have mainly focused on six major metabolic pathways, including glycolysis, the tricarboxylic acid (TCA) cycle, the pentose phosphate pathway (PPP), amino acid metabolism, fatty acid (FA) oxidation and FA synthesis
The disorder of high-density lipoprotein (HDL), low-density lipoprotein (LDL) and total cholesterol (TC) levels has been reported in the active course of rheumatoid arthritis (RA) (Choy and Sattar, 2009), and a higher prevalence of dyslipidaemia was observed in RA patients (Garcia-Gomez et al, 2009)
Summary
Rheumatic diseases are a group of chronic autoimmune disorders that involve multiple organs or systems and have high mortality. The mechanisms of these diseases are still illdefined, and targeted therapeutic strategies are still challenging for physicians. Recent research indicates that cell metabolism plays important roles in the pathogenesis of rheumatic diseases. We mainly focus on lipid metabolism profiles (dyslipidaemia, fatty acid metabolism) and mechanisms in rheumatic diseases and discuss potential clinical applications based on lipid metabolism profiles. Edited by: Jian Gao, Second Affiliated Hospital of Dalian Medical University, China. Reviewed by: Hai-Feng Pan, Anhui Medical University, China Sheng Wang, Fifth People’s Hospital of Suzhou, China.
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