LIPID METABOLISM IN EXPERIMENTAL PANCREATIC DIABETES I. BLOOD AND LIVER LIPIDS OF DOGS FASTED DURING TOTAL INSULIN DEPRIVATION1

Abstract

THE OBSERVATION THAT the pancreas contains, besides insulin, a factor (or fac-tors) controlling lipid metabolism of blood and liver made necessary a reinves-tigation of the lipid changes that are to be ascribed to the absence of the anti-diabetic hormone per se. It was previously shown that no rise need occur in the cholesterol, phospholipids or fatty acids of the blood when depancreatized dogs re-ceive no insulin during the fasting state. Indeed, in those dogs in which a high lipid level had been established before cessation of insulin treatments, a fall in the concen-tration of alj lipid constituents followed the withdrawal of both food and insulin. The present study deals with the blood lipid changes resulting from insulin depriva-tion during nutritional states in which diets were fed containing a) raw pancreas and b) meat, but none of the glandular tissue.