Abstract
The intracellular delivery of proteins and other bioactive molecules using membrane-permeable carrier peptide vectors is a way to elucidate and control cell functions with therapeutic potentials. One of the most typical peptide vector is a short arginine-rich peptide segment derived from the human immunodeficiency virus (HIV)-1Tat protein as well as various arginine-rich oligopeptides. These peptides seems to translocate with their cargo into eukaryotic cells through a physical mechanism which is neither receptor-mediated and does not implicate endocytosis.
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