Abstract
Lipid Mediators in Skin Inflammation: Updates and Current Views
Highlights
Their function in the modulation of ROS, RNS, cytokine, and chemokine production and release, in DNA and protein oxidation, in gene expression, in the regulation of antioxidant and detoxifying enzymes, is under extensive investigation. Their control may well represent a feasible tool for clinical interventions aiming at the correct modulation of skin physiological functions for possible disease prevention. In line with these concepts, the articles contributing to this issue provide new information or review current status of research on the etiological role of lipid molecules and their metabolites in acute or chronic inflammatory states of the skin compartment, induced by endogenous diseases or environmental factors
Systemic and topical lipid oxidation is a key mechanism involved in chronic inflammatory skin diseases, among which psoriasis, acne, atopic, and seborrheic dermatitis are the most compelling examples, as presented by S
Pietrzak et al More extensively, the dysregulation of the strict homeostatic systems active in the skin to maintain the redox balance and counteract abnormal oxidative stress in chronic inflammatory skin diseases is widely analysed, with special attention to how this highly controlled mechanism is affected by therapeutic intervention
Summary
In line with these concepts, the articles contributing to this issue provide new information or review current status of research on the etiological role of lipid molecules and their metabolites in acute or chronic inflammatory states of the skin compartment, induced by endogenous diseases or environmental factors. Editorial Lipid Mediators in Skin Inflammation: Updates and Current Views
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