Abstract
The role transmembrane helices (TMH) play in biological systems includes creating ion transport pathways, cell signaling and facilitating photon absorption in photosynthetic complexes. The packing and spatial organization of those helices was found to be important for their functional properties. It was shown (Walters & DeGrado, PNAS (2006); 13, 37) that despite the large number of available conformations, experimentally observed helix-helix interactions can be classified into very few interaction clusters.
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