Abstract
to analyze adherence of FH patients with familial hypercholesterolemia (FH) to the statin therapy and reveal factors, which influence it;to assess the degree of target level of low-density lipoprotein cholesterol (LDLCH) achievement by FH patients on statin therapy. Materials andmethods. We included in this study 203 FH patients aged >18 years (mean age 50.0±1.1 years, 82 men). Definite FH was diagnosed in 96 persons,in the other patients FH was considered possible. For evaluating the adherence to therapy with statins we used the Morisky-Green questionnaire.Results. Among patients with definite FH 57 % were adherent to lipid-lowering therapy, 16 % were partially adherent, and 27 % - notadherent. Target LDLCH levels were achieved in 22.6 % and 12.5 % of patients with definite and possible FH, respectively. Smoking and genderwere not associated with adherence to statin therapy. Factors associated with higher adherence were age (p=0.000003), arterial hypertension(odds ratio [OR] 1.90, 95 % confidence interval [CI] 1.02 to 3.55], p=0.044), ischemic heart disease (IHD) (OR=2.99, 95 %CI 1.50 to 5.97,p=0.002), history of myocardial infarction (MI) (OR 5.26, 95 %CI 2.03 to 13.60, p=0.0006), history of myocardial revascularization (OR 20.3,95 %CI 2.64 to 156.11, p=0.004) and the fact of achieving target LDLCH level (OR 19.93, 95 %CI 7.03 to 56.50, p<0.0001). The main reasonfor the refuse from statin therapy in 87 % of patients was fear of side effects. Main reasons for stopping of ongoing therapy were: myalgia, an increasein transaminases, skin rashes, and high cost in 12, 35, 12, and 6 % of patients, respectively. The decision to withdraw therapy with statinswas made by 29 % of patients by themselves. In this study 57 % of patients with definite FH were adherent to statin therapy. Factorsassociated with increased adherence were age, hypertension, IHD, history of MI, history of myocardial revascularization, achievement of targetLDLCH level. Target LDLCH levels were achieved by 22.6 and 12.5 %% of patients with definite and possible FH, respectively.
Highlights
Результаты анализа приверженности пациентов с СГХС с помощью метода логистической регрессии
Результаты анализа приверженности пациентов с СГХС с помощью метода логистической регрессии представлены в табл. 5
4. Karpov Ju.A., Bojcov S.A., Kuharchuk V.V. Consensus Statement of the Russian National Atherosclerosis Society (RNAS) Familial hypercholesterolemia in Russia: outstanding issues in diagnosis and management
Summary
Aim: to analyze adherence of FH patients with familial hypercholesterolemia (FH) to the statin therapy and reveal factors, which influence it; to assess the degree of target level of low-density lipoprotein cholesterol (LDLCH) achievement by FH patients on statin therapy. Отдельной проблемой является низкая приверженность пациентов с СГХС к гиполипидемической терапии [10]. Частота выявления мутаций рецептора ЛНП у пациентов с определенной СГХС в Карелии составила 42,3 %, выявленные мутации характеризовались разнообразием, уникальностью и отсутствием эффекта основателя. При постановке диагноза учитывали общепринятые критерии: наличие семейного анамнеза, отягощенного по сердечно-сосудистым заболеваниям (ССЗ): раннее развитие ССЗ у родственников первой степени родства – у мужчин моложе 55 лет, у женщин моложе 60 лет; наличие ИБС или атеросклеротического поражения другого сосудистого бассейна у самого пациента; наличие родственника первой степени родства с гиперхолестеринемией; уровень ХС ЛНП у пациента и наличие характерных стигм СГХС (сухожильные ксантомы, липоидная дуга роговицы у лиц моложе 45 лет). Для проверки статистической значимости различия средних между группами применяли критерий Стьюдента или однофакторный дисперсионный анализ (ANOVA) в случаях с нормальным распределением показателей.
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