Abstract
Grape seed extract (GSE) has been targeted to promote beneficial health effects, especially the prevention of obesity and hyperlipidemia. In present study, we investigated the mechanisms of GSE on inhibition of lipid digestion and absorption. GSE significantly inhibited pancreatic lipase and cholesterol esterase in dose-dependent manner with the IC50 values of 3.71 ± 0.03 and 27.27 ± 4.12 mg/mL, respectively. In addition, GSE also inhibited the formation of cholesterol micelles, and bound to bile acid. The oral administration of GSE significantly decreased serum triglyceride and cholesterol in rat fed high fat emulsion through inhibition of lipid digestion and absorption. GSE may be a feasible therapeutic strategy for prevention and treatment of patients with hyperlipidemia and obesity. Key words: Grape seed extract, bile acid binding, cholesterol micellization, pancreatic cholesterol esterase, pancreatic lipase, mechanisms.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
