Lipid‐lowering effect of extracellular polyphenol extracts from Lachnum singerianum in high‐fat diet‐fed mice

Abstract

Lachnum singerianum polyphenol (LSP) was obtained from its fermentation broth using the organic solvent method. A high-fat mouse model was used to determine the lipid-lowering effect of LSP. Results showed that lipid levels of mice were reduced in varying degrees by different doses of LSP, and the high-dose group showed the most significant lipid-lowering effects. Body weight gain, feed efficiency, and liver indexes of the high-dose groups decreased 45.5%, 47.3% and 28.8%, respectively. Compared with the model group, total cholesterol, triglyceride, and low-density lipoprotein cholesterol levels and atherosclerosis index in high-dose group reduced by 23.20%, 44.95%, 47.06%, and 62.31%, respectively. In the high-dose groups, similar results were observed for activities of alanine aminotransferase and aspartate aminotransferase decreased, respectively, by 31.7%, and 22.9%. The activities of superoxide dismutase, catalase glutathione, and catalase in the serum and liver were significantly activated, and swelling and fat vacuoles in the liver were reduced. Practical applications Extracellular polyphenol extract produced by Lachnum singerianum have lipid-lowering effect, and could be explored as a potentially promising food and drug additive for the treatment of hyperlipidemia.