Lipid Lowering Activity of Anthocephalus indicus Root in Hyperlipidemic Rats

Vishnu Kumar,Ranjana Singh,Raj Kumar Singh,Ashok Kumar Khanna,Mohammad Mubin Khan,Abbas Ali Mahdi,Farzana Mahdi,Sushma Singh,Ramesh Chander,Jitendra Kumar Saxena

doi:10.1093/ecam/nen001

Abstract

The lipid lowering activity of Anthocephalus indicus (family Rubiaceae; Hindi name Kadamba) root extract has been studied in triton WR-1339 induced hyperlipidemia in rats. In this model, feeding with root extract (500 mg kg−1 b.w.) lowered plasma lipids and reactivated post-heparin lipolytic activity in hyperlipidemic rats. Furthermore, the root extract (50–500 μM) inhibited the generation of superoxide anions and hydroxyl radicals, in both enzymic and non-enzymic systems, in vitro. The results of the present study demonstrated both lipid lowering and antioxidant activities in root extract of A. indicus, which could help prevention of hyperlipidemia and related diseases.

Highlights

Disorders of lipid metabolism, hyperlipidemia, hypertension and obesity are associated with increased oxidative stress and overproduction of oxygen free radicals [1]
There have been reports that the lipid lowering drugs: fibrates, statins and bile acid sequestraints used for the treatment of hyperlipidemia associated disorders do not possess antioxidant
Anthocephalus indicus: the cadamba Miq is one such Ayurvedic remedy that has been mentioned in many Indian medical literatures for the treatment of fever, anemia, uterine complaints, menorrhigia, blood and skin diseases, diarrhea, colitis, stomatitis, dysentery and in improvement of semen quality [6,7]

Summary

Introduction

Hyperlipidemia, hypertension and obesity are associated with increased oxidative stress and overproduction of oxygen free radicals [1]. Hyperlipidemia following oxidative stress may cause oxidative modifications in lowdensity lipoproteins, which play an important role in the initiation and progression of atherosclerosis and related cardiovascular diseases [3]. There have been reports that the lipid lowering drugs: fibrates, statins and bile acid sequestraints used for the treatment of hyperlipidemia associated disorders do not possess antioxidant. Anthocephalus indicus: the cadamba Miq (family Rubiaceae, Hindi name; Kadamba) is one such Ayurvedic remedy that has been mentioned in many Indian medical literatures for the treatment of fever, anemia, uterine complaints, menorrhigia, blood and skin diseases, diarrhea, colitis, stomatitis, dysentery and in improvement of semen quality [6,7].

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Conclusion