Abstract
Purpose of Investigation: The aim of this study was to find new markers for detection of ovarian neoplasms. Authors decided to compare the lipid indicies in the blood serum of patients undergoing surgery treatment of mature ovarian teratomas. Lack of data on this subject in accessible literature was a stimulating factor for this study. Materials and Methods: The examinations covered two groups of women, each with 32 persons. Fasting blood serum gained from blood samples was analysed, marking before the surgical procedure, on the 7th day, six and 12 months after the procedure. Correlations between lipid indices changes HDL/TCH, HDL/LDL, and ApoA1/ApoB was analysed with use of Spearman correlation test. Results: In all parameters of the lipid metabolism and lipid indices, similar direction of changes - that is a trend direction, has been observed. Conclusions: Lipid indices showed their usefulness in preoperational monitoring, the effectiveness of treatment, and postoperative monitoring of mature ovarian teratomas.
Highlights
Mature teratomas occur in young women with a frequency of about 25% of all ovarian cancers [1–4]. They arise from moved germ cells and mostly occur in the form of dermoid cyst containing thick fluid and mature tissues, such as tallow, hairs or bone tissues [5]
Clinical mature ovarian teratomas fall within benign germ-cell tumours, in solid forms malignant character of the tumour can arise
It can be considered that lipid indices meet stricter criteria in comparison to single parameters of lipid metabolism in diagnosis of a lot of illnesses [12,15,16]
Summary
Mature teratomas (teratoma adultum) occur in young women with a frequency of about 25% of all ovarian cancers [1–4]. They arise from moved germ cells and mostly occur in the form of dermoid cyst (cystis dermoidalis) containing thick fluid and mature tissues, such as tallow, hairs or bone tissues [5]. Clinical mature ovarian teratomas fall within benign germ-cell tumours, in solid forms malignant character of the tumour can arise. The purpose of the present work, with the use of previous examination results, is the diagnostic role of the selected lipid indices in the women blood serum, subject to the procedure of removal of mature teratomas [9, 10]
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