Abstract
AbstractBackgroundSpecific metabolic changes during physiological pregnancy are characterized by hyperlipidemia and increased oxidative stress. However, these specific changes raise the question of their pro-atherogenic potential during pregnancy and their influence on the risk of developing cardiovascular disease (CVD) in women later in life, as well as complications during pregnancy. The aim of this study was to investigate the changes in lipid indexes and parameters of lipid peroxidation in non-complicated pregnancy in order to estimate their course of change and potential relationship during non-complicated pregnancy.MethodsThe study included 43 healthy pregnant women and 38 non-pregnant healthy women, in appropriate ages, as the control group. Lipid parameters and oxidative stress parameters were monitored in a longitudinal study in the first, second and third trimesters, and before delivery during non-complicated pregnancy.ResultsResults have shown that lipid indexes rise during pregnancy. The values were significantly increased when compared to the first trimester in all lipid indices and in comparison with the control group. Thyobarbituric acid reactive substances (TBARS) and lipid hydroperoxides (LOOH) were not changed significantly during physiological pregnancy, but LOOH showed a significantly higher value in the first trimester compared with the control group. Prooxidative-antioxidative balance (PAB) significantly increases as pregnancy progresses.ConclusionsWe observed the changes in lipids, lipid indexes and parameters that indicate oxidative modification of lipids in physiological pregnancy that may lead to an atherogenic, prooxidant state.
Highlights
Non-complicated pregnancy is a dynamic state accompanied by specific metabolic changes
Non-complicated pregnancy is associated with alterations in the composition and size of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles, which become smaller and denser with higher pro-atherogenic potential and decreased atheroprotective potential [6, 7]
Data are expressed as mean ± SD; ameans and 95th confidence intervals derived from log-normal values. bSignificantly different from 1st trimester; csignificantly different from 2nd trimester; dsignificantly different from 3rd trimester; esignificantly different from 38th week gestation. fp < 0.05, gp < 0.001 (Tukey’s post hoc test). hp < 0.05 (Student’s t-test), ip < 0.001 (Student’s t-test). apoA-I, apolipoprotein A-I; apoB, apolipoprotein B; CHOL, cholesterol; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TG, trigylcerides
Summary
Non-complicated (physiological) pregnancy is a dynamic state accompanied by specific metabolic changes Among these changes, the most interesting for researchers in the last couple of years were specific lipid profile and oxidative stress status, because of their potential influence on women’s health later in life and their influence on cardiovascular disease (CVD) development [1,2,3]. Specific metabolic changes during physiological pregnancy are characterized by hyperlipidemia and increased oxidative stress These specific changes raise the question of their pro-atherogenic potential during pregnancy and their influence on the risk of developing cardiovascular disease (CVD) in women later in life, as well as complications during pregnancy. Conclusions: We observed the changes in lipids, lipid indexes and parameters that indicate oxidative
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