Abstract
The Omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) generate bioactive lipid mediators that reduce inflammation. The present study evaluated the effect of SMOFlipid containing ω-3 PUFAs on wound healing. Rats were divided into a SMOFlipid (SMOF) group and a 0.9% saline (placebo) group, with eight rats in each group. Wound excision was performed on the dorsal surface of each rat. In the SMOF group, 1gm/kg SMOFlipid was dissolved in 3mL saline as a treatment; in the placebo group, 3mL saline was prepared as a treatment. The treatments were administered intravenously at an initial rate of 0.2mL/kg body weight/h immediately after wounding, for 72h. Blood samples were collected for white blood cell, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-10 measurements at the baseline and at 1, 6, 12, 24, 48, and 72h after intervention. Wound areas were measured over a 2-week period after excision, and a histological examination was performed. Compared with the placebo group, SMOFlipid supplementation engendered significant decreases in the wound area on day 3 (78.28±5.25 vs. 105.86±8.89%), day 5 (72.20±4.31 vs. 96.39±4.72%), day 10 (20.78±1.28 vs. 39.80±10.38%), and day 14 (7.56±0.61 vs. 15.10±2.42%). The placebo group had a higher TNF-α level than the SMOF group at 72h. The IL-10 level was higher in the SMOF group than in the placebo group at 48h. Histological analysis revealed a higher rate of fibroblast distribution and collagen fiber organization in the SMOF group (P=0.01). SMOFlipid enriched in ω-3 PUFA accelerates wound healing.
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