Abstract
Model membranes have been used to describe the interaction between charged drugs (acridine orange, ethidium bromide) and lipids. A new method of evaluation of the surface charge density is described. It allows, from surface potential measurements, the evaluation of the drug-lipid association constant. The low perturbation of the monolayer dipole orientation after complexation is correlated to the low penetration of the drug into the lipid bilayer of liposomes as shown by a fluorescence titration technique.
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