Abstract
Aspirin (Asp), acetyl salicyclic acid, is a drug widely used as an analgesis, an antipyretic and, in particular, as an inhibitor of platelet aggregation. Recently, a lipid perturbation mechanism for drug action has been given much priority as it is critically important for the rearrangements of membrane surface proteins, receptors, etc. In the present paper we have reported the lipid-ordering effect of Asp in the liposomal membrane of dipalmitoyl phosphatidyl choline from a fluorescence anisotropy study of a membrane-embedded fluorescent probe, 1,6-diphenyl-1,3,5-hexatriene. The result of our study indicates that the drug Asp disorders the liposomal membrane. This probably arises because of the structure (flat ring) of Asp, and the fact that its lipophilicity is greater than its hydrophilicity (solution spectrum); it also accounts for the analgesic as well as inhibitory effects of Asp on platelet aggregation.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
