Abstract
The incorporation of DL [3- 14C]serine and N-acetyl [4- 14C] neuraminic acid into neuron-enriched and glial-enriched lipid fractions was studied. The neuronal-enriched fraction incorporated 14C-label into gangliosides to a greater extent than the glial-enriched fractions, substantiating previous indications that the neurons are the principal site of ganglioside biosynthesis in the brain.
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